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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Vet Pathol. 2017 Feb 8;54(4):710–719. doi: 10.1177/0300985817691582

Figure 14.

Figure 14

Chronology of disease in enterohemorrhagic Escherichia coli-monocolonized gnotobiotic mice. (a) Neutrophilic colitis is present 1 day after infection and plateaus thereafter. (b) Acute tubular necrosis (ATN) is detectable in some mice by day 4 PI and continues to increase in severity as urine specific gravity decreases (c). (d) Concentration of Stx in feces peaks at day 11 PI. The figure includes previously published data (days 8 and 11)8,39 as well as data from this study. *Significantly different from uninfected. ◊Significantly different from day 4.