Table 3.
Association of ABCC4 −1508A>G polymorphism with clinical features, metabolite, and cytokine profiles in asthmatic patients.
| Clinical features | AA (n = 305) | AG/GG (n = 48) | P value |
|
| |||
| Age (years)† | 39.01 ± 14.34 | 40.92 ± 15.09 | 0.735 |
| Sex, male (%)‡ | 32.14 | 28.57 | 0.335 |
| Atopy (%)‡ | 57.46 | 51.18 | 0.928 |
| Total IgE (IU/mL)† | 451.48 ± 965.78 | 278.32 ± 319.68 | 0.240 |
| Rhinosinusitis (%)‡ | 81.21 | 18.78 | 0.143 |
| Nasal polyp (%)‡ | 81.11 | 18.88 | 0.889 |
| FEV1 (%)† | 86.45 ± 19.66 | 87.54 ± 14.57 | 0.638 |
| PC20 methacholine (mg/mL) | 10.19 ± 17.07 | 5.82 ± 8.04 | 0.119 |
| Total IgE | 451.48 ± 965.78 | 278.32 ± 319.69 | 0.24 |
| Asthma duration (years)† | 6.30 ± 6.03 | 12.81 ± 32.36 | 0.237 |
|
| |||
| Inflammatory cytokines | AA (n = 121) | AG/GG (n = 26) | P value |
|
| |||
| MPO (μg/L)† | 108.26 ± 79.5 | 150.91 ± 94.13 | 0.027 |
| IL-8 (pg/mL)† | 16.82 ± 14.45 | 14.47 ± 7.5 | 0.616 |
| IL-18 (pg/mL)† | 247.77 ± 166.06 | 281.92 ± 197.10 | 0.560 |
| Eotaxin-1 (ng/mL)† | 85.67 ± 63.67 | 85.22 ± 65.11 | 0.841 |
| Eotaxin-2 (ng/mL)† | 1146.92 ± 802.14 | 1104.95 ± 641.09 | 0.650 |
| Periostin (ng/mL)† | 71.07 ± 33.62 | 91.83 ± 50.85 | 0.016 |
|
| |||
| Serum metabolites (ng/mL) | AA (n = 43) | AG/GG (n = 17) | P value |
|
| |||
| 15-HETE | 265.98 ± 185.69 | 334.34 ± 132.47 | 0.195 |
| LTE4 | 18.22 ± 17 | 18.8 ± 14.71 | 0.731 |
| PGF2α | 23.55 ± 9.3 | 21.96 ± 8.69 | 0.653 |
| TXB2 | 0.41 ± 0.42 | 0.39 ± 0.17 | 0.952 |
| Eoxin C4 | 4.82 ± 9.5 | 8.14 ± 11.95 | 0.224 |
| S1P | 111.75 ± 42.16 | 120.91 ± 42.88 | 0.419 |
|
| |||
| Urinary metabolites (pmol/mg Cr) | AA (n = 23) | AG/GG (n = 8) | P value |
|
| |||
| 15- HETE | 271.91 ± 89.87 | 332.5 ± 99.31 | 0.032 |
| LTE4 | 7648.29 ± 14378.31 | 2601.73 ± 3043.59 | 0.616 |
| PGF2α | 8618.51 ± 22942.8 | 1678.71 ± 978.76 | 0.65 |
| TXB2 | 5686.61 ± 4305.7 | 4798.25 ± 3957.21 | 0.765 |
| Eoxin C4 | 144.78 ± 94.07 | 124.75 ± 46.65 | 0.602 |
| S1P | 32.56 ± 8.25 | 41.5 ± 9.35 | 0.010 |
†Values were presented as mean ± SD, whereas ‡ values were shown as percentage. Cr: creatinine; LTE4: leukotriene E4; PGF2α: prostaglandin F2α; TXB2: thromboxane B2; 15-HETE: 15-hydroxyeicosatetraenoic acid; MPO: myeloperoxidase; S1P: sphingosine-1-phosphate. P value was obtained by logistic regression analysis with age and sex as covariates.