Table 3.

Multiple Linear Regression Analyses for Interleukin 1B (IL1B) rs1143629, Interleukin 1R2 (IL1R2) HapA2, and Nuclear Factor Kappa, Beta 2 Subunit (NFKB2) rs7897947 to Predict Low to High Trait Anxiety (n=234)

Predictor of Low to High Trait Anxiety	β Coefficient	Standard Error	95% CI	t	p-value
IL1B rs1143629	2.980	1.248	.520, 5.440	2.39	.018
Age	−.875	.283	−1.433, −.318	−3.10	.002
Functional status	−1.843	.529	−2.884, −.801	−3.49	.001
Number of comorbidities	.588	.231	.132, 1.044	2.54	.012
Overall model fit: F(10,223) = 5.31, p <.0001 R2 = .1923
IL1R2 HapA2 genotype	2.744	1.236	.308, 5.180	2.22	.027
Age	−.875	.283	−1.434, −.317	−3.09	.002
Functional status	−1.766	.528	−2.808, −.725	−3.34	.001
Number of comorbidities	.563	.232	.105, 1.020	2.42	.016
Overall model fit: F(10,223) = 5.22, p <.0001 R2 = .1895
NFKB2 rs78979947	−2.698	1.217	−5.096, −.301	−2.22	.028
Age	−.897	.283	−1.454, −.340	−3.17	.002
Functional status	−1.826	.529	−2.869, −.783	−3.45	.001
Number of comorbidities	.534	.233	.074, .994	2.29	.023
Overall model fit: F(10,223) = 5.21, p<.0001 R2 = .1895

For this model, the first three principle components identified from the analysis of ancestry informative markers as well as self-reported race/ethnicity (White, Asian/Pacific Islander, Black, Hispanic/Mixed Ethnic Background/Other) were retained to adjust for potential confounding due to race or ethnicity (data not shown). Predictors evaluated in the model included genotype (IL1B rs1143629: TT versus CT+CC; IL1R2 HapA2: composed of IL1R2 rs4141134 [rare “C” allele], rs11674595 [common “T” allele], and rs7570441 [common “G” allele]; and NFKB2 rs7897947: TT versus TG+GG), age (in 5-year increments), functional status (Karnofsky Performance Status score, in 10-point increments), and number of comorbidities.