Table 2.
In vitro cytotoxicity of compounds 3a–p
| Compound | IC50a (μM)
|
||||
|---|---|---|---|---|---|
| HeLa | MDA-MB-231 | MiaPaca-2 | MCF-7 | MCF-10 | |
| 3a | 18.64 | IAb | IA | IA | IA |
| 3b | 28.31 | IA | 26.12 | 32.81 | IA |
| 3c | 27.19 | IA | 28.47 | 32.81 | IA |
| 3d | 29.00 | IA | IA | IA | IA |
| 3e | 29.00 | IA | IA | IA | IA |
| 3f | 28.01 | IA | 27.08 | IA | IA |
| 3g | 24.12 | 26.90 | 26.29 | 32.81 | IA |
| 3h | 28.65 | 29.16 | 27.32 | IA | IA |
| 3i | 25.15 | 26.50 | 26.33 | 32.13 | IA |
| 3j | 32.87 | 28.00 | 23.19 | 28.48 | IA |
| 3k | 27.20 | IA | IA | 31.49 | IA |
| 3l | 25.79 | 31.21 | 26.38 | 32.19 | IA |
| 3m | 27.36 | 28.54 | 27.44 | 32.29 | IA |
| 3n | 25.60 | 30.71 | 27.10 | 31.10 | IA |
| 3o | 29.12 | IA | 27.55 | 31.73 | IA |
| 3p | IA | IA | IA | IA | IA |
| Shikonin | 6.42 | 3.94 | 0.04 | 5.49 | 4.56 |
a
IC50 values were calculated from three independent experiments.
b
IA = inactivity. Inactivity is defined as having greater than 50% cell at the highest concentration (33.3 μM).