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. Author manuscript; available in PMC: 2017 Jun 19.
Published in final edited form as: Bioorg Med Chem Lett. 2016 Apr 6;26(11):2691–2694. doi: 10.1016/j.bmcl.2016.04.006

Table 3.

In vitro cytotoxicity of compounds 4a–c

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Compound R1 R2 IC50a (μM)
HeLa MDA-MB-231 MiaPaca-2 MCF-7 MCF-10
4a H H 29.19 28.77 27.65 IA IA
4b/4b′ 7-Br/8-Br H 6.22 6.25 6.55 6.57 28.14
4c/4c′ 7-Br/8-Br CH3 25.95 26.28 IAb 28.74 IA
Shikonin 6.42 3.94 0.04 5.49 4.56
Doxorubicin 0.03 0.16 0.02 1.17 0.16
a

IC50 values were calculated from three independent experiments.

b

IA = inactivity. Inactivity is defined as having greater than 50% cell at the highest concentration (33.3 μM).