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. 2016 Dec 24;16:51–62. doi: 10.1016/j.ebiom.2016.12.012

Fig. 1.

Fig. 1

TVB-3166 and TVB-3664 small molecule FASN inhibitors. (A) Chemical structure of TVB-3166 and TVB-3664. (B) Pharmacokinetic analysis of TVB-3664 in mice. Drug levels were determined from 3 different mice for each time point following administration by oral gavage or intravenous injection. (Bayside Biosciences, San Jose, CA). For oral dosing, TVB-3664 was formulated at 3-V Biosciences in 100% PEG-400 and diluted with water to a final PEG concentration of 30% immediately before dosing. For iv dosing TVB-3664 was formulated Bioanalytical analysis was performed at 3-V Biosciences by mass spectrometry.