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. 2017 Jan 16;16:124–135. doi: 10.1016/j.ebiom.2017.01.014

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© 2017 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig. 1. — Serum neutralization activity upon natural RSV infection.

(a) Sera were subjected to a microneutralization assay to determine neutralization titers against RSV A2 strain. A left panel represented neutralization titer in acute phase or convalescent phase, and a right panel did the GMRs C/A of NT. The mean ± 95% CI was estimated by linear model, and was shown in the graphs. Neutralization titer in acute phase: 0–3 mo, n = 34; 4–6 mo, n = 30; 7–12 mo, n = 33; 13–18 mo, n = 35; 19–36 mo, n = 35; adults, n = 23. Neutralization titer in convalescent phase: 0–3 mo, n = 35; 4–6 mo, n = 30; 7–12 mo, n = 34; 13–18 mo, n = 35; 19–36 mo, n = 35; adults, n = 23. GMRs C/A of NT: 0–3 mo, n = 34; 4–6 mo, n = 30; 7–12 mo, n = 33; 13–18 mo, n = 35; 19–36 mo, n = 35; adults, n = 23. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001. (b) Sera, which showed high neutralization activity against RSV A2 in panel (a), were subjected to a microneutralization assay to evaluate NT against RSV 18537 strain. Children: r = 0.705, p < 0.0001 (n = 24), adults: r = 0.657, p = 0.0012 (n = 21). (c) Neutralization titers were also analyzed in two distinct groups according to RSV groups infected during the research period to evaluate the cross neutralization activity at convalescent phase. Group A: 0–3 mo, n = 20; 4–6 mo, n = 16; 7–12 mo, n = 17; 13–18 mo, n = 25; 19–36 mo, n = 21; adults, n = 12. Group B: 0–3 mo, n = 14; 4–6 mo, n = 11; 7–12 mo, n = 13; 13–18 mo, n = 6; 19–36 mo, n = 8; adults, n = 5. The mean ± 95% CI was estimated by the linear model, and were shown in the graphs. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.