Fig. 5.
The correlation between the serum neutralization activity and the antibody affinity maturation to F protein.
Two-dimensional plots were prepared to investigate the correlation between serum neutralization titer (NT) and kd. Red arrows represents the changes from acute phase to convalescent phase to show an apparent positive correlation between IgG binding stability and NT, i.e., increase of kd accompanied with decrease of NT or decrease of kd with increase of NT. Green arrows represents the changes to show an apparent negative correlation between IgG binding stability and NT. In each age group, regression coefficient of NT on kd was calculated. 0–3 mo, n = 34; 4–6 mo, n = 30; 7–12 mo, n = 34; 13–18 mo, n = 35; 19–36 mo, n = 34; adults, n = 23.