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. 2017 Jun 19;9:11. doi: 10.3389/fnsyn.2017.00011

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Copyright © 2017 Wong, Stowell and Majewska.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Developmental EtOH exposure activates microglia and impairs their homeostatic functions. (A) Developmental EtOH exposure causes acute microglial activation which produces: 1. Activation and production of inflammatory signals 2. Increased neuronal death and phagocytosis. (B) Developmental EtOH exposure produces changes in dendritic spine density and could impact microglial interactions with synapses. 3. A number of microglia-neuron signaling systems could be disrupted and contribute to spine density changes including: complement dependent pruning, decreased CX3CR1 signaling altered BDNF release.