Figure 6.
Tail suspension test of Epm2b+/− (control) and Epm2b−/− (KO) mice untreated (w/o TTT) or treated with trehalose, 4-PBA or metformin, during one (A) or two months (B). Percentage of Epm2b+/− (control) or Epm2b−/− (KO) mice showing normal posture (0) or altered (1) stereotypical clasping of the hind-limb upon tail suspension (n: 8–11 in each group). Significant differences between the groups were indicated (*p< 0.05, **p< 0.01) according to the Fisher exact test followed by Wilcoxon-Mann-Whitney test.