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. Author manuscript; available in PMC: 2017 Jun 19.
Published in final edited form as: Mol Neurobiol. 2015 Jan 28;53(2):1296–1309. doi: 10.1007/s12035-015-9091-8

Figure 7.

Figure 7

Vertical pole test for evaluation of motor coordination of Epm2b+/− (control) and Epm2b−/− (KO) mice untreated (w/o TTT) or treated with trehalose, 4-PBA or metformin, during one (A–B) or two months (C–D). After one month of treatment, the time taken by the mice to turn completely downward (time to turn) (A) and the total time taken to reach the floor (locomotion activity) (B) were recorded. After two months of treatment, the time to turn (C) and the locomotion activity (D) were also recorded. Bars indicate mean of values corresponding to eight to twelve mice ± SEM. Asterisks denote significant differences between the groups (*p< 0.05, **p< 0.01, ***p< 0.001) according to Kruskal-Wallis non-parametric test followed by Conover-Inman post-hoc test).