Open-field analyses of Epm2b+/− (control) and Epm2b−/− (KO) mice untreated (w/o TTT) or treated with the described drugs during one month (A, C, E, G) or two months (B, D, F, H). No significant differences between groups (n: 8–12 mice in each group) were observed in all recorded parameters: total distance roamed (A–B), total immobility time (C–D), number of entries in the more central zone (zone 3) (E–F), or the distance roamed in zone 3 (G–H), according to Kruskal-Wallis non-parametric test followed by Conover-Inman post-hoc test.