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. 2017 Jun 19;8:340. doi: 10.3389/fphar.2017.00340

FIGURE 5.

FIGURE 5

Naringenin ameliorates recognition memory deficits and AD pathologies in 5XFAD mice. (A) Time course of behavioral tests. Naringenin (0, 5, or 100 mg kg-1 per day) was orally administered to 5XFAD mice (male, 8–12 months old, n = 4–5) for 29 days, and their behavioral performance was evaluated. (B) Total distance moved (within 10 min) in the open-field test. (C) Object recognition test. The preferential indices for the training and test sessions are shown. p = 0.009, drug × time interaction was analyzed using repeated measures two-way ANOVA, F(3,11) = 6.24. ∗p < 0.05 vs. vehicle-treated 5XFAD mice, post hoc Bonferroni test. (D) The total area of amyloid plaques, PHF-tau associated with amyloid plaques, and swollen axons associated with amyloid plaques were measured in the perirhinal cortex and hippocampus. One-way ANOVA and Dunnett’s post hoc test were performed in all statistical analyses (∗p < 0.05 vs. vehicle-treated 5XFAD mice).