Fig. 2.

B-cell function gene mutations in diffuse large B-cell lymphoma (DLBCL).

(A) Gene mutations identified by targeted sequencing in 275 patients with DLBCL. (B) Number and type of non-silent somatic mutations. (C) Number and percentage of non-silent somatic SNVs (6 most frequent SNVs were listed on the Figure). (D) Schematic description of B-cell function genes. The key mutated genes are indicated, including MYD88, CARD11, TNFAIP3, LYN, CD79A, CD79B and TRAF2. COO: cell of origin; DE: double BCL-2/MYC expression; GCB: germinal center B-cell.