Table 1.
Antibacterial activity of L-BMAP18 and D-BMAP18 against Gram-positive and Gram-negative strains from CF patients.
| L-BMAP17 (μg/ml) | D-BMAP18 (μg/ml) | |||||
|---|---|---|---|---|---|---|
| Strains | MICa* | MBCa* | KQb | MICa | MBCa | KQb |
| P. aeruginosa | ||||||
| PA01 | 8 | 8 | 1 | 8 | 32 | 4 |
| RP73 | 32 | 32 | 1 | 4 | 8 | 2 |
| PA03 | 8 | 16 | 2 | 8 | 8 | 1 |
| PA05 | 4 | 8 | 2 | 4 | 8 | 2 |
| PA07 | 4 | 8 | 2 | 8 | 8 | 1 |
| PA08 | 8 | >32 | >4 | 8 | 16 | 2 |
| PA09 | 16 | >32 | >2 | 16 | 32 | 2 |
| PA10 | >32 | >32 | − | 16 | 32 | 2 |
| PA14 | 8 | 32 | 4 | 16 | 32 | 2 |
| PA21 | 8 | 32 | 4 | 16 | 32 | 2 |
| PA22 | 2 | 8 | 2 | 4 | 32 | 8 |
| PA31 | 8 | 16 | 2 | 16 | 32 | 2 |
| S. maltophilia | ||||||
| SM103 | 4 | 8 | 2 | 4 | 4 | 1 |
| SM105 | 8 | >32 | >4 | 8 | 8 | 1 |
| SM106 | >32 | >32 | − | 32 | 32 | 1 |
| SM110 | 4 | 8 | 2 | 4 | 4 | 1 |
| SM120 | 16 | >32 | >2 | 8 | 16 | 2 |
| SM122 | >32 | >32 | − | 16 | 16 | 1 |
| SM123 | 32 | 32 | 1 | 16 | 16 | 1 |
| SM126 | 32 | >32 | >1 | 16 | 32 | 2 |
| SM130 | 8 | 8 | 1 | 8 | 16 | 2 |
| SM136 | 8 | 8 | 1 | 8 | 16 | 2 |
| SM139 | 8 | 16 | 2 | 8 | 8 | 1 |
| SM143 | 4 | 16 | 4 | 8 | 8 | 1 |
| S. aureus | ||||||
| SA1 | >32 | − | − | >32 | − | − |
| SA2 | >32 | − | − | >32 | − | − |
| SA3 | >32 | − | − | >32 | − | − |
| SA4 | 32 | − | − | >32 | − | − |
| SA5 | 32 | − | − | >32 | − | − |
| SA7 | 32 | − | − | >32 | − | − |
Minimum inhibiting (MIC) and minimum bactericidal (MBC) concentrations are shown. Results are from three independent experiments performed as internal duplicates (n = 6).
*
These data were already published (Mardirossian et al., 2016).
a
MIC and MBC values are expressed as μg/ml.
b
KQ, killing quotient, measured as MBC/MIC ratio: KQ ≤ 4 is suggestive for bactericidal effect, KQ > 4 is suggestive for bacteriostatic effect.