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Cell growth inhibitory activity of reference BET inhibitors 1–3 and new compounds 17–19 in acute leukemia cell lines.
| Compound | IC50 (nM) | ||
|---|---|---|---|
| MV4; 11 | MOLM-13 | K562 | |
| 1 | 24±19 | 56±24 | >2000 |
| 2 | 93±45 | 241±58 | >2000 |
| 3 | 162±112 | 228±52 | >2000 |
| 17 | 23±10 | 78±12 | >2000 |
| 18 | 20±9 | 66±14 | >2000 |
| 19 | 34±15 | 144±31 | >2000 |
