Table 2.
(a) Regions of gray matter volume reduction in patients with amyotrophic lateral sclerosis relative to controls. (b) Region of gray matter positively correlated with total Frontal Assessment Battery score in patients with amyotrophic lateral sclerosis
| Anatomical region | BA | Talairach coordinates | Cluster size | Voxel T‐value | Z score | Cluster p value | Uncorrected voxel p value | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| x | y | z | FWE | FDR | Uncorrected | ||||||
| (a) | |||||||||||
| Left precentral gyrus | 6 | −52.5 | 3.6 | 13.6 | 226 | 6.20 | 5.08 | .222 | .125 | .013 | <.001 |
| Right rectal gyrus | 11 | 11.9 | 22.1 | −23.8 | 511 | 5.40 | 4.60 | .011 | .011 | .001 | <.001 |
| Left middle frontal gyrus | 11 | −22.8 | 24.4 | −16.4 | 237 | 4.71 | 4.13 | .196 | .125 | .012 | <.001 |
| (b) | |||||||||||
| Right orbitofrontal gyrus | 11 | 23.8 | 36.8 | −22.0 | 4 | 4.70 | 3.78 | .029 | .565 | .565 | <.001 |
BA, Brodmann's area; FWE, family‐wise error; FDR, false discovery rate.