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. 2017 Jun 13;8:15762. doi: 10.1038/ncomms15762

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Copyright © 2017, The Author(s)

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Examples of drugs and late-stage drug candidates where Suzuki-Miyaura coupling is used to form key carbon–carbon bonds (shown in blue) with heterocyclic coupling partners. (b) The Suzuki-Miyaura reaction is strategically powerful in drug synthesis and design due to its robustness and tolerance of heterocycles. (c) This work: asymmetric Suzuki-Miyaura coupling to form Csp³–Csp² bonds using heterocycles where X, Y or Z≠CH.