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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: J Immunol. 2017 May 1;198(11):4255–4267. doi: 10.4049/jimmunol.1700024

Figure 7. DIDS treatment inhibits T1D development.

Figure 7

Starting at 6 (A), 8 (B), or 10 (C) weeks of age female NOD mice were treated with vehicle, or DIDS at 10 mg/kg or 50 mg/kg on a weekly basis and monitored for T1D development. P-values were calculated using Mantel-Cox analysis. (D) Serum was harvested from the cohort of mice in (A) at the initiation of treatment and retrospectively typed for IAA. Graph represents the percent of IAA+ or IAA- mice in each treatment group that did or did not progress to T1D (IAA+ DIDS: n= 9; IAA+ Vehicle: n=3; IAA- DIDS: n=11; IAA- Vehicle: n=7). P-values were calculated using Fisher's exact test. (E) Insulitis scores for NOD female mice treated weekly starting at 8 weeks of age with vehicle (n=10) or DIDS at a dose of 10 mg/kg (n=8) or 50 mg/kg (n=14). P-values were calculated using Mann-Whitney analysis showing Mean±SEM.