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. 2017 May 30;114(24):E4753–E4761. doi: 10.1073/pnas.1702560114

Table 2.

Categorization of SLC transporters detected in human yolk sac tissue

Substrate category	SLC transporters detected in human yolk sac	Known substrates	Substrates detected in human coelomic fluid
Amino acids	SLC38A2^^,^†, SLC7A7^, SLC7A2, SLC1A5^, SLC38A3, SLC3A2^, SLC3A1^†, SLC25A38^, SLC38A4^, SLC38A10^, SLC25A13^^,^†, SLC7A8^, SLC7A6^^,^†, SLC43A1^, SLC7A4, SLC7A9^, SLC1A4^, SLC38A7^^,^†, SLC7A1^, SLC15A4^^,^†, SLC38A5^, SLC7A6OS^^,^†, SLC43A3^^,^†, SLC38A9^^,^†, SLC43A2^^,^†, SLC36A4^, SLC38A6^*^,^†, SLC38A11, SLC6A17, SLC7A10	Ala, Asn, Cys, Gln, Gly, His, Met, Pro, Ser, Glu, Trp, Asp	Thr, His, Arg, Val, Met, Ile, Leu, Phe, Lys, Ser, Gln, Glu, Tau, Ala, Pro, Tyr, Orn, Trp (21, 22, 25–27)
Urea cycle	SLC25A15^*^,^†, SLC2A9^†	Lys, Orn, Cit, Asp, Glu, uric acid	Urea (28, 29)
Glucose and sugars	SLC2A1^^,^†, SLC2A3^^,^†, SLC2A4RG, SLC50A1^, SLC2A2^^,^†, SLC1A1^†, SLC2A10^†, SLC2A14, SLC5A9^, SLC45A4^, SLC2A8^, SLC2A12, SLC2A6, SLC2A13^†, SLC37A1, SLC2A5^†, SLC37A2^†, SLC2A7^, SLC45A1, SLC2A11, SLC2A1-AS1	Glucose, galactose, fructose, mannose, glucosamine	Glucose, galactose, fructose, mannose, glucosamine, galactosamine, erythritol, ribitol, mannitol, inositol, glycerol, sorbitol (22, 30)
Nucleoside sugars	SLC35D2^, SLC17A9^, SLC35E2B^†, SLC29A1^, SLC35C2^^,^†, SLC35A4^^,^†, SLC35A2^, SLC35E1^^,^†, SLC25A36^^,^†, SLC35D1^^,^†, SLC35A5^^,^†, SLC35F5^^,^†, SLC37A4^^,^†, SLC35F6^, SLC35A3^^,^†, SLC37A3^^,^†, SLC35B1^^,^†, SLC35C1^, SLC52A2^, SLC29A2^, SLC29A3^, SLC35B4^^,^†, SLC35G1^, SLC35E3^^,^†, SLC29A4, SLC35F2^^,^†, SLC35F3, SLC25A19^, SLC35G2^, SLC28A1^*	UDP-glucuronic acid, UDP-galactose, UDP-N-acetyl-galactosamine, GDP-fructose
Metals	SLC30A5^^,^†, SLC30A9^^,^†, SLC40A1^^,^†, SLC39A7, SLC39A14^^,^†, SLC25A37^^,^†, SLC39A6^, SLC39A5^, SLC39A1^, SLC30A1^^,^†, SLC31A1^^,^†, SLC25A28^^,^†, SLC39A13^^,^†, SLC39A9^^,^†, SLC39A8^^,^†, SLC11A2^^,^†, SLC30A6^^,^†, SLC30A7^, SLC41A1^, SLC41A3^, SLC39A11^^,^†, SLC30A10^^,^†, SLC31A2^, SLC39A10^, SLC41A2^†, SLC30A2^, SLC39A4^, SLC11A1, SLC39A3^, SLC30A4^*^,^†	Zinc, iron, magnesium, copper, cadmium, cobalt, manganese, nickel, lead, barium, strontium	Zinc, iron, cadmium, magnesium, copper, manganese, lead, selenium (28, 31, 32)
Vitamins	SLC19A2^, SLC46A3^^,^†, SLC25A32^^,^†, SLC23A2^, SLC5A6^, SLC46A1^^,^†, SLC23A1^, SLC19A3^, SLC19A1^, SLC23A3^	Thiamine (vitamin B₁), folate, ascorbic acid, biotin, lipoate, pantothenate, thiamine	Vitamins A, E, B₁₂, folate, cobalamin, retinol-binding protein 4, vitamin D-binding protein (21, 27, 29, 33–35)
Neurotransmitters	SLC44A2^, SLC44A4^, SLC6A6^^,^†, SLC44A1^^,^†, SLC36A1^^,^†, SLC6A9^^,^†, SLC1A3^, SLC6A13^, SLC44A3^†, SLC17A2, SLC25A22^^,^†, SLC25A18, SLC25A12^^,^†, SLC17A4, SLC6A12	Noradrenaline, serotonin, dopamine, glutamate, glycine, aspartate, choline	Glutamine, glutamic acid (21, 25)
Inorganic ions	SLC25A3^^,^†, SLC9A3R1^, SLC4A1^^,^†, SLC20A1^, SLC12A7^^,^†, SLC4A2^^,^†, SLC9A3R2^, SLC34A2^^,^†, SLC12A4^^,^†, SLC26A6^, SLC9A1^, SLC20A2^, SLC9A6^^,^†, SLC4A1AP^, SLC9A9^†, SLC26A11^^,^†, SLC9B2, SLC26A2^, SLC24A3, SLC9A8^, SLC12A8, SLC8B1^, SLC12A2^^,^†, SLC24A1, SLC4A7^, SLC12A6^, SLC4A3, SLC26A10, SLC26A1^, SLC5A5, SLC9A7P1, SLC9A5^, SLC8A1, SLC4A4^	Na⁺, K⁺, Cl⁻, HCO₃⁻, Ca²⁺, phosphate	Na⁺, K⁺, Cl⁻, HCO₃⁻, Ca²⁺, phosphate (28, 29)
Thyroid	SLC16A2^†, SLC7A5^^,^†, SLC16A10^^,^†	Iodide, iodothyronines	Tyrosine, thyroxine (26)
Organic ions	SLCO2B1^†, SLC22A7, SLC10A1, SLC10A3^, SLC22A23^^,^†, SLC51A^, SLC22A9, SLC22A17^, SLCO4C1^, SLCO2A1^, SLC22A31, SLC22A18^^,^†, SLC22A4^, SLC22A5^^,^†, SLC10A7^^,^†, SLC51B, SLCO1B3, SLC22A15, SLC22A18AS, SLCO1B1, SLCO3A1^^,^†, SLC17A3, SLC22A3^	Estradiol, glucuronide, bilirubin	Bilirubin
Miscellaneous	SLC25A5^, SLC5A12, SLC25A39^^,^†, SLC25A1^^,^†, SLC16A3^, SLC35B2^, SLC25A20^, SLC17A5^^,^†, SLC16A1^^,^†, SLC16A4^†, SLC13A5, SLC35B3^, SLC6A8^, SLC27A2^^,^†, SLC25A24^^,^†, SLC25A23^, SLC25A11^, SLC25A44^, SLC25A25^, SLC45A3^, SLC15A1^, SLC25A46^, SLC25A27, SLC25A42^, SLC27A3^, SLC25A17^^,^†, SLC25A43^^,^†, SLC35A1^^,^†, SLC12A9^^,^†, SLC16A5, SLC25A29^†, SLC18B1^, SLC16A13^^,^†, SLC25A30^^,^†, SLC27A4^^,^†, SLC16A9^^,^†, SLC48A1^^,^†, SLC33A1^^,^†, SLC25A4^, SLC25A14^^,^†, SLC25A33^, SLC25A16^^,^†, SLC25A40^, SLC25A34^, SLC27A1^^,^†, SLC25A26^, SLC47A1^^,^†, SLC15A3, SLC16A12^^,^†, SLC25A45^, SLC5A11^, SLC25A51^, SLC13A3^^,^†, SLC16A14, SLC25A21-AS1, SLC16A7^†, SLC16A6^, SLC15A2, SLC27A5^, SLC17A1	ATP-ADP, carnitine, creatinine, acetyl-CoA, sialic acid, pyruvate, lactate, ketone bodies, bile acids, oxoglutarate, succinate, citrate, ketoglutarate, ornithine, acylcarnitine, melanin, prostaglandin, long-chain and very long-chain fatty acids, haem, ammonia, adenosine, taurocholic acid	Lactate, creatinine (29, 30)

^*

Also present in the mouse yolk sac.

^{^†}

Also present in the chick yolk sac.