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. Author manuscript; available in PMC: 2018 May 3.
Published in final edited form as: Neuron. 2017 Apr 13;94(3):581–594.e5. doi: 10.1016/j.neuron.2017.03.043

Figure 4. Lipidomic profiling of brain versus lung capillaries reveals different lipid signatures, including changes in DHA-containing phospholipid species. See also Figures S4 and S5; Table S3.

Figure 4

(A) Dot plot representation of lipidomic profiling of brain versus lung capillaries from P4 wild-type mice. Dots represent average lipid level in the brain (x-axis) and lung (y-axis) for each metabolite tested, expressed as mass spectrometry integrated peak area. Red dots indicate DHA-containing phospholipid species. (B) DHA-containing phospholipid levels are increased in brain capillaries. Lipidomic analysis of DHA-containing phospholipid species from brain and lung capillaries of P4 wild-type mice. Value for each species is normalized to internal standard and expressed as integrated mass spectrometry peak area. (LPE, lyso-phosphatidylethanolamine; PC, phosphatidylcholine; PE, phosphatidylethanolamine; PS, phosphatidylserine). * P < 0.004 (Student’s t-test, with Bonferroni correction for multiple comparisons). For all data, n = 6 groups per organ, 8 animals pooled per group.