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. 2017 Apr 27;25(6):1316–1327. doi: 10.1016/j.ymthe.2017.03.035

Figure 3.

Figure 3

A Single Dose of H10 mRNA in Ferrets Generates Robust HAI Titers, Which Are Significant and Comparable at All Time Points

Ferrets were vaccinated ID with 50 or 100 μg formulated H10 mRNA. p < 0.0001, days 21, 35, and 49 versus day 0 with single doses of 50 or 100 μg; p < 0.0001 100-μg single dose, day 7 versus day 0. A subset of immunized ferrets received a boost on day 21 and an additional subset received a second boost on day 35. HAI titers were measured on days 0, 7, 21, 35, and 49 (n = 8/group). p < 0.0001 50 or 100 μg boosting dose(s), days 35 and 49 versus day 0.