Fig. 6.

Insulin-induced increases in DAT-mediated DA uptake in CPu and NAc as a function of diet. Freshly prepared CPu or NAc synaptosomes were pre-incubated with or without 30 nM insulin (+Ins) for 15 min at 37ºC before assessing 0.25 μM DA uptake with RDEV. Data are presented as percentage of initial DA uptake rate treated with 30 nM insulin compared to vehicle (PBS) AL control for each striatal subregion (dotted line = 100%). Data reflect means ± SEM from 5–8 independent experiments, *p<0.05 vs. vehicle control, ^#p<0.05 vs. AL control (one-way ANOVA followed by Dunnett’s post hoc test). ^δp<0.05 vs. AL of CPu (two-tailed Student’s t-test). N.s. nonsignificant.