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. Author manuscript; available in PMC: 2017 Jun 19.
Published in final edited form as: J Probiotics Health. 2017 Jan 2;5(1):159. doi: 10.4172/2329-8901.1000159

Figure 1.

Figure 1

LR and LP pretreatment protects against EGTA- and LPS-induced decreases in barrier resistance. Caco-2 cells were untreated (Control) or pretreated for 2 hours with probiotics (LR–panels A and C or LP–panels B and D) before undergoing TJ disruption by EGTA calcium switch (panels A and B) or LPS treatment (panels C and D). TER was measured at each time point after treatment with membrane disrupting reagents. (A) LR pretreatment increased TER in the absence (p<0.0014) and presence of EGTA (p<0.0001). (B) LP pretreatment also increased TER in the absence (p<0.0059) and presence of EGTA (p<0.0009) as compared to those cells treated with EGTA alone. (C) LR pretreatment increased TER in the absence (p<0.0001) and presence of LPS (p<0.042). (D) LP pretreatment had less of an effect on TER in the absence (p<0.043) and presence of LPS (p<0.047).