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. 2017 May 26;61(1):1325307. doi: 10.1080/16546628.2017.1325307

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© 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Schematic diagram showing the possible mechanisms(s) of brown adipose tissue thermogenesis and mitochondrial biogenesis by dietary epigallocatechin-3-gallate (EGCG) in diet-induced obese mice. AMPK, AMP-activated protein kinase; ACC2, acetyl-coenzyme A carboxylase-2; carnitine-palmitoyl-coenzyme A transferase-1; UCP1, uncoupling protein 1; UCP2, uncoupling protein 2; PRDM16, PR domain containing 16; PGC-1α, peroxisome proliferator-activated receptor gamma coactivator-1α; NRF1, nuclear respiratory factor-1; Tfam, mitochondrial transcription factor A; mtDNA, mitochondrial DNA.