Table 1.
Immunological parameters before and after hematopoietic stem cell transplantation.
| Pre-transplant | Post-transplant |
1.92 years | 3.42 years | ||||
|---|---|---|---|---|---|---|---|
| D + 18 | D + 53 | D + 102 | D + 203 | ||||
| Lymphocyte subsets | |||||||
| CD3 | 12 | 994 | 438 | 1,877 | 6,621 | 3,239 | 2,065 |
| CD8 | 9 | 703 | 204 | 1,331 | 5,551 | 2,164 | 1,053 |
| CD4 | 3 | 296 | 218 | 518 | 1,013 | 996 | 925 |
| NK | 52 | 40 | 52 | 122 | 283 | 147 | 139 |
| CD19 | 9 | 26 | 9 | 72 | 146 | 106 | 92 |
| DR+ (%) | – | 84 | 70 | 86 | 77 | 54 | 46 |
| CD45RA/CD27+ | – | 20 | – | – | 728 | 586 | 372 |
| CD19+/CD27+/IgM− | – | – | – | – | – | 6% | 9% |
| Chimerism (%) | |||||||
| Donor CD3 | – | 96 | 96 | 100 | 100 | 93 | 93 |
| Donor CD19 | – | – | – | – | – | – | 20 |
| Donor CD15 | – | 5% | 10 | 6 | 5 | 5 | 5 |
| Immunoglobulins | |||||||
| IgG | <0.3 | 9.4a | 16.6a | 7.2a | 9.0a | 3.4 | 4.7 |
| IgA | <0.04 | <0.04 | <0.04 | 0.15 | 0.43 | 0.37 | 0.55 |
| IgM | <0.05 | <0.50 | 0.05 | 0.25 | 0.95 | 0.24 | 0.41 |
| Tetanus | 0.04 | – | – | – | – | 0.18b | 4.26c |
| Hib | <0.01 | – | – | – | – | 0.5b | >9.0c |
aOn IVIG.
bPre-vaccination, off IVIG replacement.
cPost-vaccination.