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. 2017 Jun 19;8:135. doi: 10.3389/fendo.2017.00135

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Copyright © 2017 Lindqvist, Shcherbina, Fischer and Wierup.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Glucagon-like peptide 1 (GLP-1) secretion was increased in mice receiving ghrelin intravenously (50 nmol/kg) (A). AUC calculations revealed a statistically significant increase in GLP-1 after ghrelin injection (B). Insulin (C), glucose-dependent insulinotropic peptide (GIP) (D), and glucose (E) were unaffected by ghrelin treatment. Hyperghrelinemia in the mice was confirmed by significantly elevated levels of circulating ghrelin in the group of mice having received intravenous administration of ghrelin (F). *p < 0.05; ***p < 0.001. All statistical analyses were performed using two-way ANOVA except for (B) where Student’s t-test was applied.