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. 2017 Jun 15;8:690. doi: 10.3389/fimmu.2017.00690

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Copyright © 2017 Kleynhans, Ruzive, Ehlers, Thiart, Chegou, Conradie, Kriel, Stanley, van der Spuy, Kidd, van Helden, Walzl and Ronacher.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in circulating hormone concentrations during the course of tuberculosis (TB) treatment. Plasma from TB patients (males and females) who were cured (n = 25) and who failed (n = 10) TB treatment were collected before (baseline) and during TB treatment (week 4 and month 6). Plasma collected was subjected to hormone measurement by Luminex analysis [cortisol (A), T3 (D), T4 (E), ghrelin (F), leptin (G), and estradiol (B)] and ELISA [dehydroepiandrosterone (DHEA) (J), amylin (Tot) (H), adiponectin (I), and growth hormone (C)]. Data were analyzed by a linear mixed-effects model of hormone concentrations by treatment outcome and time point as fixed effects and patient ID as random effect. Results are presented as means of the log-transformed data with SD. A p-value of < 0.05 was regarded as significantly different. *p-value < 0.05; **p-value < 0.01; ***p-value < 0.001.