Table 2.
Univariate COX proportional survival analysis
| No. of Points | No. of Events | Median Survival | 95% CI for Median | HR | 95% CI for HR | P Value | |
|---|---|---|---|---|---|---|---|
| Age, yr | |||||||
| Unit change | 95 | 66 | 12.62 | 6.05–19.75 | 1.00 | 0.99–1.02 | 0.618 |
| Hemoglobin, g/dl | |||||||
| Unit change | 95 | 66 | 12.62 | 6.05–19.75 | 0.78 | 0.68–0.88 | <0.001 |
| PTT | |||||||
| Unit change | 95 | 66 | 12.62 | 6.05–19.75 | 0.96 | 0.89–1.03 | 0.244 |
| INR | |||||||
| Unit change | 95 | 66 | 12.62 | 6.05–19.75 | 1.15 | 0.64–2.06 | 0.646 |
| Platelets | |||||||
| <50,000 | 2 | 2 | 2.99 | 2.99–NE | 1.00 | 0.08–1.34 | 0.118 |
| ≥50,000 | 86 | 59 | 12.62 | 6.05–18.86 | 0.32 | ||
| Creatinine, mg/dl | |||||||
| Unit change | 95 | 66 | 12.62 | 6.05–19.75 | 0.70 | 0.32–1.54 | 0.373 |
| Time for hemoptysis onset to consultation, d | |||||||
| Unit change | 95 | 66 | 12.62 | 6.05–19.75 | 0.99 | 0.99–1.00 | 0.189 |
| Time to bronchoscopy, d | |||||||
| Unit change | 95 | 66 | 12.62 | 6.05–19.75 | 0.91 | 0.82–1.00 | 0.057 |
| Gender | |||||||
| Male | 47 | 36 | 6.14 | 3.78–16.23 | 1.00 | ||
| Female | 48 | 30 | 17.28 | 7.20–66.50 | 0.61 | 0.37–0.99 | 0.044 |
| Ethnicity | |||||||
| White | 71 | 47 | 15.84 | 5.59–33.87 | 1.00 | ||
| Black | 13 | 10 | 6.34 | 3.48–9.40 | 1.42 | 0.71–2.81 | 0.321 |
| Hispanic | 8 | 7 | 6.14 | 0.69–20.80 | 1.58 | 0.71–3.51 | 0.265 |
| Asian | 3 | 2 | 17.28 | 17.28–NE | 1.08 | 0.26–4.46 | 0.913 |
| Basal malignancy | |||||||
| Lung cancers | 46 | 33 | 7.33 | 4.93–16.23 | 1.00 | ||
| Other cancers | 49 | 33 | 17.25 | 5.29–47.70 | 0.80 | 0.49–1.30 | 0.362 |
| Smoking | |||||||
| Positive | 22 | 15 | 17.28 | 4.24–NE | 1.00 | ||
| Negative | 73 | 51 | 7.89 | 5.55–18.86 | 1.27 | 0.71–2.25 | 0.423 |
| Heart | |||||||
| No | 52 | 38 | 12.88 | 5.98–20.80 | 1.00 | ||
| Yes | 43 | 28 | 8.54 | 5.29–42.48 | 0.89 | 0.55–1.45 | 0.641 |
| Lung | |||||||
| No | 42 | 33 | 7.20 | 4.24–17.25 | 1.00 | ||
| Yes | 53 | 33 | 20.80 | 6.34–58.38 | 0.63 | 0.39–1.03 | 0.064 |
| Kidney | |||||||
| No | 90 | 62 | 12.62 | 6.05–18.86 | 1.00 | ||
| Yes | 5 | 4 | 19.75 | 2.99–NE | 1.07 | 0.39–2.93 | 0.901 |
| Liver | |||||||
| No | 93 | 64 | 12.62 | 6.05–19.75 | 1.00 | ||
| Yes | 2 | 2 | 6.14 | 6.14–NE | 1.36 | 0.33–5.59 | 0.668 |
| Antiplatelet therapy | |||||||
| No | 77 | 56 | 8.54 | 5.59–17.25 | 1.00 | ||
| Yes | 16 | 10 | 18.86 | 3.48–NE | 0.73 | 0.37–1.44 | 0.368 |
| Anticoagulant therapy | |||||||
| No | 90 | 62 | 12.88 | 6.14–19.75 | 1.00 | ||
| Yes | 4 | 4 | 1.87 | 1.02–NE | 2.62 | 0.95–7.24 | 0.063 |
| ECOG PS | |||||||
| PS 0 | 10 | 4 | NR | 7.98–NE | 1.00 | ||
| PS 1 | 49 | 32 | 20.80 | 6.34–58.38 | 2.29 | 0.81–6.47 | 0.119 |
| PS 2 | 25 | 21 | 5.98 | 3.81–9.40 | 4.35 | 1.48–12.76 | 0.007 |
| PS 3 | 11 | 9 | 2.99 | 1.12–12.62 | 6.51 | 1.98–21.41 | 0.002 |
| Active bleeding | |||||||
| No-AB | 55 | 29 | 42.48 | 16.23-NE | 1.00 | ||
| AB | 40 | 37 | 4.01 | 2.99-5.55 | 3.65 | 2.22–6.02 | <0.001 |
| Blood transfusion | |||||||
| No | 88 | 60 | 15.24 | 7.20-21.19 | 1.00 | ||
| Yes | 6 | 5 | 2.99 | 0.66-NE | 2.27 | 0.91–5.69 | 0.080 |
| Resolved in 48 h | |||||||
| No | 20 | 17 | 4.40 | 2.99-7.89 | 1.00 | ||
| Yes | 75 | 49 | 16.23 | 7.98-39.75 | 0.50 | 0.28–0.87 | 0.014 |
| Active bleeding and endobronchial lesion | |||||||
| No-AB/no-EBL | 45 | 22 | 66.50 | 20.80-NE | 1.00 | ||
| No-AB/EBL | 10 | 7 | 8.15 | 0.95-NE | 2.40 | 1.02–5.66 | 0.045 |
| AB/no-EBL | 10 | 8 | 4.40 | 2.99-8.54 | 2.96 | 1.31–6.71 | 0.009 |
| AB/EBL | 30 | 29 | 3.48 | 2.14-6.05 | 4.93 | 2.78–8.74 | <0.001 |
| Endobronchial lesion | |||||||
| No-EBL | 55 | 30 | 39.75 | 12.62-NE | 1.00 | ||
| EBL | 40 | 36 | 4.21 | 2.14-7.98 | 3.30 | 2.01–5.44 | <0.001 |
| Stage | |||||||
| Early | 19 | 4 | NR | 66.50-NE | 1.00 | ||
| Advanced | 76 | 62 | 6.14 | 4.40-12.62 | 8.81 | 3.17–24.46 | <0.001 |
Definition of abbreviations: AB = active bleeding; CI = confidence interval; EBL = endobronchial lesion; ECOG = Eastern Cooperative Oncology Group; INR = international normalized ratio; NE = not estimable; NR = not reached; PS = performance status; PTT = partial thromboplastin time.