Table 4.

Transplant variables significant on logistic regression analysis of hematopoietic stem cell transplantation patients with or without pulmonary complications

Characteristic	P Value	OR	95% CI	Reference
Univariate Analysis*
CMV-positive donor	0.03	1.54	1.04–2.29	CMV-neg
T-cell depletion	<0.0001	2.33	1.56–3.48	T-replete
Acute grade 3–4 GVHD	<0.0001	3.05	1.75–5.31	Others
Chronic GVHD	0.05	1.61	1.00–2.60	None
Infection	0.0002	4.78	2.10–10.88	None
FEF25–75%	0.03	2.61	1.10–6.20
FEF25–75% GLI-2012	0.01	2.88	1.26–6.54
Multivariate Analysis†
T-cell depletion	0.001	0.33	0.16–0.66	T-replete
Acute grade 3–4 GVHD	0.008	0.45	0.25–0.85	Others
Chronic GVHD	0.01	0.46	0.25–0.85	None
Infection	0.006	0.20	0.06–0.63	None
FEF25–75%	0.02	3.21	1.16–8.86
Multivariate Analysis Using GLI-2012 Predicted Values
T-cell depletion	0.002	0.36	0.19–0.70	T-replete
Acute grade 3–4 GVHD	0.004	0.45	0.26–0.78	Others
Chronic GVHD	0.04	0.55	0.31–0.97	None
Infection	0.005	0.23	0.08–0.65	None
FEF25–75% GLI-2012	0.01	3.32	1.29–8.50

Definition of abbreviations: CI = confidence interval; CMV = cytomegalovirus; FEF_{25–75% GLI-2012} = forced expiratory flow during the midportion of the forced vital capacity as calculated by the Global Lungs Initiative 2012, in liters/second; GVHD = graft-versus-host disease; neg = negative; OR = odds ratio.

^*For univariate analysis, the probability modeled for CMV donor status, T-cell depletion, acute GVHD grade 3–4, chronic GVHD, and infection as the contributing cause of death was patients with pulmonary complications (reference group is patients with no pulmonary complications). However, for variables FEF_25–75% and FEF_{25–75% GLI-2012}, expressed in liters/second, the probability modeled was patients with no pulmonary complications (reference group is patients with pulmonary complications).

^†For multivariate analysis, the probability modeled was patients with no pulmonary complications for all the variables (reference group is patients with pulmonary complications).