Table 5.
Transplant variables significant for overall survival on multivariate analysis
| Characteristic* | P Value | HR | 95% CI |
|---|---|---|---|
| Age | 0.001 | 1.06 | 1.02–1.10 |
| Acute GVHD (ref none) | 0.04 | 1.38 | 1.01–1.83 |
| Chronic GVHD (ref none) | 0.0005 | 0.50 | 0.34–0.73 |
| TBI (ref none) | 0.004 | 1.70 | 1.18–2.46 |
| PFT | P Value | HR | 95% CI | PFTGLI-2012 | P Value | HR | 95% CI |
|---|---|---|---|---|---|---|---|
| FEV1 (ref ≥80%; L) | 0.0005 | FEV1 GLI-2012; L | 0.004 | ||||
| <60% | 0.01 | 2.08 | 1.18–3.66 | 0.0004 | 2.59 | 1.53–4.37 | |
| 60–69% | 0.0004 | 3.73 | 1.79–7.77 | 0.38 | 1.39 | 0.65–2.95 | |
| 70–79% | 0.92 | 0.97 | 0.56–1.67 | 0.89 | 1.03 | 0.66–1.60 | |
| FVC (ref ≥80%; L) | 0.0005 | FVCGLI-2012; L | 0.0008 | ||||
| <60% | 0.001 | 2.61 | 1.46–4.64 | 0.005 | 2.27 | 1.27–4.05 | |
| 60–69% | 0.005 | 2.92 | 1.37–6.20 | 0.002 | 2.75 | 1.45–5.23 | |
| 70–79% | 0.40 | 1.22 | 0.76–1.96 | 0.77 | 0.93 | 0.59–1.48 | |
| TLC (ref ≥80%; L) | <0.0001 | ||||||
| <60% | <0.0001 | 4.78 | 2.56–8.93 | ||||
| 60–69% | 0.26 | 1.35 | 0.79–2.30 | ||||
| 70–79% | 0.24 | 1.25 | 0.86–1.82 |
| PFT | P Value | HR | 95% CI |
|---|---|---|---|
| RV (ref ≥50%; L) | |||
| <50% | 0.01 | 1.69 | 1.11–2.56 |
| RLD (ref none) | 0.01 | 1.48 | 1.08–2.03 |
| LFS (ref category I)† | 0.10 | ||
| Category II | 0.43 | 1.12 | 0.83–1.52 |
| Category III | 0.03 | 1.66 | 1.03–2.69 |
Definition of abbreviations: CI = confidence interval; GVHD = graft-versus-host disease; HR = hazard ratio; LFS = Lung Function Score; PFT = pulmonary function test; PFTGLI-2012 = pulmonary function test as calculated according to Global Lungs Initiative 2012; ref = reference; RLD = restrictive lung disease; RV = residual volume; TBI = total body irradiation.
*
Values for age/acute GVHD/TBI calculated for FVC.
†
Category I, normal; category II, mildly abnormal; category III, moderately abnormal.