Table 1.
Effect of tested flavonolignans on the viability of Hepa1c1c7 cells.
| Compound | Concentration | Viability (% of control) |
|---|---|---|
| DMSO | 0.1% | 100 |
| SB | 12.5 μM | 107.9 ± 9.9 |
| DHSB | 5 μM | 104.5 ± 10.9 |
| SC | 50 μM | 122.4 ± 7.7 |
| DHSC | 25 μM | 96.5 ± 9.0 |
| SD | 50 μM | 118.3 ± 9.5 |
| DHSD | 50 μM | 101.5 ± 15.7 |
| Triton X-100 | 1.5% | 0 |
Hepa1c1c7 cells were treated for 48 h with 0.1% DMSO (control), 1.5% Triton X-100 (positive control) or with indicated concentrations of silybin (SB), 2,3-dehydrosilybin (DHSB), silychristin (SC), 2,3-dehydrosilychristin (DHSC), silydianin (SD) or 2,3-dehydrosilydianin (DHSD). Cell viability was determined by MTT assay. Data are means ± standard deviation of three independent experiments. The table shows the results for the highest flavonolignan concentrations tested in the NQO1 assay.