Table 2.

Change in Clinical and Safety Measures Over Time

	Coefficient	df	F Value	P Value
MoCA Total
Intercept	−3.5512	—	—	—
Sequence	0.4238	1,17	0.25	0.6249
Phase	0.2740	1,17	0.14	0.7082
Drug	−0.02209	1,17	0.00	0.9759
GDS (Total)
Intercept	−3.3653	—	—	—
Sequence	0.09099	1,17	0.03	0.8638
Phase	−0.1512	1,17	0.18	0.6778
Drug	0.01959	1,17	0.00	0.9580
DSRS (Total)
Intercept	0.8501	—	—	—
Sequence	0.2240	1,16	0.08	0.7820
Phase	−1.1462	1,16	2.46	0.1364
Drug	−0.3780	1,16	0.26	0.6153
Plasma Glucose
Intercept	39.6331	—	—	—
Sequence	1.8683	1,17	0.31	0.5877
Phase	−0.1037	1,17	0.00	0.9733
Drug	−2.1645	1,17	0.51	0.4852
Plasma Insulin
Intercept	−1.0065	—	—	—
Sequence	0.9853	1,4	2.51	0.1886
Phase	0.4067	1,4	0.43	0.5473
Drug	−0.7626	1,4	1.34	0.3119
BMI
Intercept	−0.4425	—	—	—
Sequence	−0.05314	1,15	0.08	0.7795
Phase	0.1058	1,15	0.57	0.4619
Drug	−0.3737	1,15	5.27	0.0365
Plasma Lactate
Intercept	−0.1533	—	—	—
Sequence	0.02860	1,40	0.26	0.6124
Phase	—	2,40	2.46	0.0986
Drug	0.1253	1,40	4.16	0.0481