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. 2017 Jun 19;12(6):e0179589. doi: 10.1371/journal.pone.0179589

Table 5. Frequency rate and adjusted risk of maternal morbidity, SGA-birth and spontaneous preterm delivery during second pregnancy in relation to change in BMI between first and second pregnancy, and BMI category at second pregnancy booking.

Model 1- second pregnancy outcome
Maternal Morbidity SGA-birth Spontaneous Preterm <37weeks
Number of affected pregnancies Rate (%) 1139 (22.4%) 467 (9.2%) 324 (6.4%)
Categorical predictors
  BMI gain vs. stable, Pregnancy 1–2 OR(95% CI) 1.32 (1.09–1.60)** 0.81 (0.60–1.11) 0.98 (0.65–1.48)
  BMI loss vs. stable, Pregnancy 1–2 OR(95% CI) 1.14 (0.84–1.57) 1.88 (1.24–2.85)** 1.41 (0.78–2.57)
At Pregnancy 2
  Obese vs. normal OR(95% CI) 1.38 (0.96–1.99) 1.18 (0.67–2.10) 0.82 (0.31–1.60)
  Overweight vs. normal OR(95% CI) 1.19 (0.97–1.45) 0.80 (0.58–1.09) 0.75 (0.48–1.15)
  Undernourished vs. normal OR(95% CI) 1.51 (0.76–2.99) 1.16 (0.57–2.36) 1.63 (0.70–3.82)
Model 2 –second pregnancy outcome
Maternal Morbidity SGA-birth Spontaneous Preterm <37weeks
Number of affected pregnancies Rate (%) 1139 (22.4%) 467 (9.2%) 324 (6.4%)
Categorical predictors
  BMI gain vs. stable, Pregnancy 1–2 OR(95% CI) 1.29 (1.06–1.56)** 0.86 (0.62–1.19) 0.96 (0.64–1.46)
  BMI loss vs. stable, Pregnancy 1–2 OR(95% CI) 1.16 (0.84–1.59) 2.07 (1.32–3.22)*** 1.41 (0.77–2.56)
At Pregnancy 2
  Obese vs. normal OR(95% CI) 1.34 (0.93–1.94) 1.26 (0.68–2.34) 0.67 (0.30–1.50)
  Overweight vs. normal OR(95% CI) 1.16 (0.94–1.41) 0.86 (0.61–1.20) 0.72 (0.47–1.12)
  Undernourished vs. normal OR(95% CI) 1.63 (0.82–3.22) 0.94 (0.43–2.04) 1.72 (0.73–4.03)

Maternal morbidity if an individual had one or more complications including pre-eclampsia, gestational hypertension, caesarean delivery or thromboembolism during second pregnancy. Odds ratios and 95% confidence limits from logistic regression

*P<0.05

**P<0.01

***P<0.001. Model 1 adjusted for baseline BMI at first pregnancy, height, inter-delivery interval between first and second pregnancy, and maternal age, year of delivery, smoking habit, gestational age and baby gender at second pregnancy. Model 2 additionally adjusted for placental weight at second delivery.