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. 2017 Jun 19;12(6):e0179589. doi: 10.1371/journal.pone.0179589

Table 6. Frequency rate and adjusted risk of maternal morbidity, SGA-birth and spontaneous preterm delivery during third pregnancy in relation to change in BMI between three consecutive pregnancies and BMI category at third pregnancy booking.

Model 1- third pregnancy outcome
Maternal Morbidity SGA-birth Spontaneous Preterm <37weeks
Number of affected pregnancies 1283 (25.3%) 402 (7.9%) 300 (5.9%)
Categorical predictors
  BMI gain vs. stable, Pregnancy 1–2 1.24 (1.04–1.49)* 0.69 (0.51–0.95)* 1.00 (0.67–1.51)
  BMI loss vs. stable, Pregnancy 1–2 0.81 (0.59–1.11) 1.09 (0.68–1.72) 1.04 (0.54–2.01)
  BMI gain vs. stable, Pregnancy 2–3 1.35 (1.12–1.61)*** 1.15 (0.87–1.54) 0.69 (0.45–1.06)
  BMI loss vs. stable, Pregnancy 2–3 0.88 (0.65–1.20) 2.23 (1.47–3.39)*** 0.67 (0.34–1.35)
At Pregnancy 3
  Obese vs. normal 1.06 (0.77–1.44) 0.56 (0.33–0.94)* 0.97 (0.49–1.94)
  Overweight vs. normal 1.07 (0.89–1.29) 0.58 (0.43–0.77)*** 0.67 (0.43–1.02)
  Undernourished vs. normal 0.58 (0.19–1.77) 1.13 (0.37–3.39) 2.76 (0.97–7.88)
Model 2- third pregnancy outcome
Maternal Morbidity SGA-birth Spontaneous Preterm <37weeks
Number of affected pregnancies 1283 (25.3%) 402 (7.9%) 300 (5.9%)
Categorical predictors
  BMI gain vs. stable, Pregnancy 1–2 1.22 (1.01–1.46)* 0.69 (0.49–0.98)* 0.96 (0.66–1.49)
  BMI loss vs. stable, Pregnancy 1–2 0.79 (0.58–1.09) 1.12 (0.68–1.84) 1.04 (0.54–2.01)
  BMI gain vs. stable, Pregnancy 2–3 1.32 (1.01–1.58)** 1.25 (0.91–1.70) 0.70 (0.45–1.07)
  BMI loss vs. stable, Pregnancy 2–3 0.92 (0.68–1.25) 2.18 (1.39–3.43)*** 0.71 (0.36–1.42)
At Pregnancy 3
  Obese vs. normal 0.97 (0.70–1.32) 0.64 (0.36–1.14) 0.91 (0.45–1.82)
  Overweight vs. normal 1.01 (0.84–1.22) 0.67 (0.49–0.93)* 0.63 (0.41–0.97)
  Undernourished vs. normal 0.57 (0.19–1.76) 1.19 (0.36–3.93) 2.78 (0.97–7.91)

Maternal morbidity if women had one or more complications including pre-eclampsia, gestational hypertension, caesarean delivery or thromboembolism at third maternity. Odds ratios and 95% confidence limits from logistic regression

*P<0.05

**P<0.01

***P<0.001. Model 1 adjusted for baseline BMI at first pregnancy, height, inter-delivery interval between first and second pregnancy, and second and third pregnancy, and maternal age, year of delivery, smoking habit, gestational age and baby gender at third pregnancy. Model 2 additionally adjusted for placental weight.