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. Author manuscript; available in PMC: 2017 Jun 19.
Published in final edited form as: Dig Dis Sci. 2015 Dec 2;61(4):1069–1079. doi: 10.1007/s10620-015-3971-7

Figure 2. Colon β-gal expression is positively correlated with epithelial damage in CACTg/WT;Rosa26Rflox/WT;ApcΔ580/WT mice following DSS treatment.

Figure 2

Mice were given increasing amounts of DSS for 5 days then examined histologically 10 days later. (A) The percentage of β-gal positive crypts in the proximal (CoP) or distal (CoD) colon. (B) The percentage of damaged epithelium (includes colon epithelial ulceration, restitution, crypt fission and other abnormal crypt structures observed during the healing process). Bars represent the mean ± SEM of 8 animals per group. Planned orthogonal comparisons were performed between no DSS vs the DSS treatment groups (# p<0.05), the low DSS vs high DSS groups (* p<0.05), and the two high DSS groups (not significant). (C) The relationship between the percentage epithelial damage and β-gal positive area in colon. The regression line for the proximal colon is shown as a dashed line. The regression line for the distal colon is shown as a solid line.