(A, D) The percentage of β-gal positive crypts was measured in proximal (A) and distal (D) colon at 10 or 30 days after ending DSS treatment. Means with different letters are significantly different (Bonferroni, p< 0.05). (B, E) The percentage of β-gal positive crypts in mucosa that exhibits a healing phenotype in the proximal (B) and distal (E) colon. Student t-tests were used to compare values between day 30 and day 10 (* p<0.05). (C, F) The percentage of βgal positive crypts in normal mucosa was measured in proximal (C) and distal (F) colon. Planned orthogonal comparisons were performed (* p<0.05, day 0 vs post-treatment values; $ p<0.05, day 10 vs day 30; # p<0.10, day 10 vs day 30). Bars represent the mean ± SEM of 8 animals per group.