Fig. 3.

Brain-predicted age in individuals with Down syndrome (DS), according to [¹¹C]-PiB status. (A) Box plot of brain-PAD (years) according to [¹¹C]-PiB status in DS participants. PiB-positive (red box) and PiB-negative (white box). Whiskers (i.e., bars) on the box plots represent the absolute range of data points for each group. (B) Scatterplot of age (x-axis) and brain-predicted age (y-axis) indicate PiB-positive DS participants (filled red circles) and PiB-negative DS participants (open red circles). Plotted are linear regression lines representing a linear fit of age regressed onto brain-predicted each, colored according to group (PiB-positive = solid red line, PiB-negative = dashed red line). Abbreviations: [¹¹C]-PiB, [¹¹C]-Pittsburgh compound B; brain-PAD, brain-predicted age difference. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)