Fig. S3.

Additional statistical parametric maps representing all fMRI associations of speech signal processing across participant groups. Significant regional brain activations for contrast of interest are shown within healthy control and patient groups (left and middle panels; T scores for relevant contrasts coded in color bars) and between groups (significantly greater activation in healthy controls than the corresponding patient group, indicated beside the panel; right-most panels). Contrasts are coded as follows (see text for details): Auditory stimulation, all sound > silence conditions; temporal, anisochronous > isochronous conditions (within-controls; controls > nfvPPA), isochronous > anisochronous conditions (within-nfvPPA); phoneme, natural > spectrally rotated speech conditions (within-controls, within-nfvPPA, within-svPPA; controls > lvPPA), spectrally rotated > natural speech conditions (within-lvPPA); entropy, high > low sequence entropy conditions. Maps are rendered on representative sections of the study-specific group mean T1-weighted structural MR image in MNI space; the plane of each section is indicated using MNI coordinates and the left cerebral hemisphere is displayed on the left in axial and coronal sections. Maps have been thresholded at p < 0.001 uncorrected over the whole brain for display purposes; all activations shown were significant at p < 0.05 after family-wise error correction for multiple comparisons (see Table 2). Abbreviations: lvPPA, logopenic variant primary progressive aphasia; nfvPPA, nonfluent variant primary progressive aphasia; svPPA, semantic variant primary progressive aphasia.