Table 2.

Final Epo population pharmacokinetic model parameter estimates and bootstrap results for a typical 3.4 kg neonate with HIE receiving hypothermia.

Population pharmacokinetic Parameters	Final Model		Bootstrap (n=1000)
	Estimate	%SE	Median	95% CI
CL (L/h)1	0.0289	4.5	0.0288	0.0263 – 0.0317
V1 (L)2	0.250	4.1	0.250	0.230 – 0.270
V2 (L)3	0.326	10.9	0.328	0.266 – 0.408
Q (L/h)4	0.0308	13.5	0.0315	0.0218 – 0.0398
Inter-patient variability
CL, %CV	20.1%	32.4	19.5%	9.6% – 25.1%
Residual variability, %CV	35.1%	13.4	35.0%	30.2% – 39.4%

CL, clearance; V₁, volume of distribution central compartment; V₂, volume of distribution peripheral compartment; Q, intercomparmental clearance; %CV, coefficient of variation × 100; %SE, relative standard error × 100; 95% CI, Bootstrap parameter estimate at the 2.5th and 97.5th percentiles.

¹ $CL(L/h)=0.0289\times {\left(\frac{\mathit{Weight}}{3.4\text{kg}}\right)}^{0.75}$

² ${\mathrm{V}}_1(L)=0.250\times \left(\frac{\mathit{Weight}}{3.4\text{kg}}\right)$

³ ${\mathrm{V}}_2(L)=0.326\times \left(\frac{\mathit{Weight}}{3.4\text{kg}}\right)$

⁴ $Q(L/h)=0.0308\times {\left(\frac{\mathit{Weight}}{3.4\text{kg}}\right)}^{0.75}$