Figure 3. The RdRp domain.
(A) In the left panel, the RdRp active site within the VSV L protein is shown, with the motifs A-D and the putative priming loop colored gold. The right panel shows the same image with residues that correspond to inhibitory substitutions in Sendai virus L shown in magenta. (B) A wider view of the image shown in panel A, from the perspective of looking through the template entry site. Corresponding amino acids were made by aligning Sendai and measles virus L protein sequences and referring to the alignment presented by Liang et al (8).