Table 2.

Automated Neuropsychological Assessment Metrics pediatric battery (Ped-ANAM) subtests

Ped-ANAM subset	Subtest description
1. Simple reaction time   (SRT)	20-item measure of reaction time. The test presents a simple stimulus on the screen (*) and the participant is required to press the left mouse key as quickly as possible following the presentation of the stimulus. This test is repeated at the end of the battery to assess both within-session reliability and the effect of fatigue on SRT performance.
2. Procedural reaction   time (PRO)	20-item measure of choice reaction time. The test presents a stimulus on the screen, a 2, 3, 4, or 5. The participant is required to press the blue (left) mouse key if a 2 or 3 is presented or the red [88] mouse key if a 4 or 5 is displayed.
3. Code substitution   (CDS) & Code   substitution delayed   (CDD)	The learning portion of this test assesses attention, concentration, and learning. In this test, a key containing a string of 9 symbols and 9 digits is displayed across the upper portion of the screen. Symbols and numbers are paired with a unique number located below a specific symbol. During the task, a “test” pair (i.e., a symbol and digit) is presented at the bottom of the screen, below the key containing the correct symbol number pairs. The objective is to indicate if the “test” pair matches the associated pair in the key at the top of the screen. The subject is instructed to try to remember the symbol-number pairs as they will be asked to recall them later. The delayed recall portion of this test is an explicit recognition memory task administered later in the test battery. For this subtest, the subject is presented only with a “test” pair and asked to remember whether the this symbol/number pairing is correct based on the earlier presented key.
4. Logical reasoning   (LRS)	This test consists of a practice and a real test in which the subject must decide if sentences presented on the screen make sense or not. Responses consist of pressing the blue (left) button if the sentence makes sense and the red [88] button if the sentence does not.
5. Spatial processing   (SPD)	Spatial processing is a test of spatial analysis and requires subjects to examine 2 bar graphs, one presented upright and one rotated 90°. They are then asked to decide if the 2 bar graphs are the same or different.
6. Continuous   performance test   (CPT)	This is a test of sustained attention and working memory. Participants are asked to monitor a randomized sequence of numbers, 1–9. The numbers are presented one at a time in the center of the screen. Participants are asked to press a response button indicating whether or not the number presented on the screen matches the number that immediately preceded it. The subject is instructed to press the blue (left) mouse button if the number matches the previous stimuli or the red [88] button if the number does not match the previous stimuli
7. Mathematical   processing (MTH)	Mathematical processing is a test of arithmetic, attention, and processing speed. The subject is required to decide if a math problem presented on the screen is correct or incorrect. Each problem includes one mathematical operation (addition or subtraction) on single-digit numbers. The subject is instructed to indicate if the problem is correct by pressing the blue (left) button or if the problem is incorrect by pressing the red [88] button.
8. Matching grids (MTG)	Matching grids is a test of visuospatial discrimination. Two 4 _ 4 grids are displayed side by side on the screen. The subject must then decide if the grids are exactly the same or different. The subject presses the blue (left) button if the grids are the same and the red [88] button if the grids are different.
9. Matching to sample   (MSP)	Matching to sample is a test of short-term memory, attention, and visuospatial discrimination. The subject is presented with a single design to study and remember. The design then disappears and the screen goes blank. Following a brief delay, 2 more designs appear on the screen. The subject must then decide which of the 2 designs matches the original. The subject presses the blue (left) button if the left comparison grid matches the original and the red [88] button if the right comparison grid matches the sample grid.
10. Sternberg memory   search (STN)	This is a test of sustained attention and working memory. Participants are presented with a set of 6 letters called the memory set (“secret code” in the pediatric version). They are allowed as long as they need to memorize the letters. Upon beginning the test, the code is removed from the screen and single letters begin appearing one at a time on the screen. The subject must then decide if the letter on the screen was contained in the secret code. The subject is instructed to press the blue (left) mouse button if the letter matches any of the letters in the secret code or the red [88] button if the letter does not match the code.