Table 1.
TA, TL, clinical characteristics, and IVF laboratory parameters of PCOS patients between the OCP pretreatment group and non-OCP pretreatment group
| Characteristics | OCP pretreatment group (N = 35) | Non-OCP pretreatment group (N = 30) | P a |
|---|---|---|---|
| TA, OD × mm, median (IQR) | 0.066 (0.059–0.087) | 0.073 (0.059–0.096) | 0.540 |
| TA level | 0.180 | ||
| TA <0.070, n (%) | 21 (60.0) | 13 (43.3) | |
| TA ≥0.070, n (%) | 14 (40.0) | 17 (56.7) | |
| TL, T:S ratio, median (IQR) | 0.890 (0.785–1.149) | 0.937 (0.793–1.131) | 0.864 |
| TL level | 0.634 | ||
| TL <1, n (%) | 23 (65.7) | 18 (60.0) | |
| TL ≥1, n (%) | 12 (34.3) | 12 (40.0) | |
| Age, years, mean ± SD | 30.1 ± 3.9 | 30.4 ± 4.7 | 0.746 |
| BMI, kg/m2, median (IQR) | 21.7 (20.4–24.0) | 21.4 (18.3–23.3) | 0.216 |
| Basal serum FSH level, IU/L, mean ± SD | 6.6 ± 2.3 | 7.0 ± 1.5 | 0.443 |
| Basal serum LH level, IU/L, median (IQR) | 6.8 (4.2–11.7) | 5.4 (4.0–7.8) | 0.202 |
| Basal serum testosterone level, nmol/L, median (IQR) | 1.9 (1.5–2.4) | 1.6 (1.0–1.9) | 0.045* |
| FSH/LHb, median (IQR) | 1.0 (0.6–1.5) | 1.2 (0.8–1.8) | 0.076 |
| Retrieved oocytes, median (IQR) | 14 (9–18) | 16 (13–20) | 0.090 |
| Total Gn dose, IU, median (IQR) | 1650 (1275–2250) | 1500 (1219–2081) | 0.470 |
| Metaphase II oocytes, median (IQR) | 13 (8–17) | 14 (11–19) | 0.168 |
| Proportion of mature oocytesc, %, median (IQR) | 92.3 (83.3–100) | 92.3 (81.8–100) | 0.846 |
| Available embryos, median (IQR) | 9 (4–13) | 9 (6–12) | 0.989 |
| Good quality embryosd, median (IQR) | 3 (1–5) | 3 (1–5) | 0.785 |
| Rate of good quality embryose, %, median (IQR) | 33.3 (14.3–55.6) | 32.1 (10.8–58.8) | 0.884 |
| Pregnancy ratef, n (%) | 17 (63.0) | 13 (54.2) | 0.524 |
| Miscarriage rateg, n (%) | 1 (5.9) | 1 (7.7) | 1.000 |
| Cumulative pregnancy rateh, n (%) | 27 (79.4) | 20 (69.0) | 0.342 |
| Cumulative rate of taking baby homei, n (%) | 23 (67.6) | 17 (58.6) | 0.458 |
| Cumulative miscarriage ratej, n (%) | 4 (14.8) | 3 (15.0) | 1.000 |
TA telomerase activity, TL telomere length, PCOS polycystic ovary syndrome, OCP oral contraceptive pill, IQR interquartile range, SD standard deviation, BMI body mass index, FSH follicle-stimulating hormone, LH luteinizing hormone
*P < 0.05 was considered statistically significant
a P values: t test for age and basal serum FSH level, Mann–Whitney U test for other continuous variables, chi-square or Fisher’s exact test for categorical variables
bFSH/LH = basal serum FSH level/basal serum LH level
cProportion of mature oocytes = metaphase II oocytes/retrieved oocytes
dGood quality embryos were embryos identified as grade A (4 cells in day 2 or 7–8 cells in day 3) or grade B (4–5 cells in day 2 or 7–9 cells in day 3) [17]
eRate of good quality embryos = good quality embryos/available embryos
fPregnancy rate = the number of pregnant patients with fresh embryo transfer/the total number of patients with fresh embryo transfer
gMiscarriage rate = the number of patients with spontaneous abortion/the total number of patients with fresh embryo transfer
hCumulative pregnancy rate was total chances of being pregnant after one IVF cycle including fresh embryo transfer and frozen embryo transfer [24]
iCumulative rate of taking baby home was total chances of successfully giving birth to a healthy baby after one IVF cycle including fresh embryo transfer and frozen embryo transfer
jCumulative miscarriage rate was total chances of spontaneous abortion after one IVF cycle including fresh embryo transfer and frozen embryo transfer