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. 2017 Jun 19;7:3796. doi: 10.1038/s41598-017-03957-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Codon usage of sFab and Fab0. In both figures, the light chain is represented in the upper and the heavy chain in the lower diagram. (a) The relative adaptiveness diagrams showing the codon usage of sFab (red) and Fab0 (black). (b) Diagrams showing the difference of codon usage frequency between sFab and Fab0. Peaks above zero indicate that a codon of Fab0 has higher frequency than the corresponding sFab codon and vice versa.