Table 2.

Fracture incidence among matched users of any insulin (N = 2,979) and non-users of insulin (N = 14,895).

Non-users of insulin (14,895)			Users of insulin (2,979)			SHR	adjSHR
N	Median follow-up (years) (IQR)	Rate (per 1000 PYs)	N	Median follow- up (years) (IQR)	Rate (per 1000 PYs)
631	4.58 (2.60–6.32)	8.26 (7.64–8.93)	60	1.42 (0.67–2.67)	11.19 (8.69–14.42)	1.43 (1.10–1.86)	1.38 (1.06–1.80)

Only the first continuous insulin use considered (switching types was accounted for), then censored. All analyses include incident insulin use as a time-dependent covariate. Analyses are PS matched at a 5:1 ratio of non-users to users. Adjusted analyses control for outstanding confounders (P < 0.1), i.e. BMI, steroids, meglitinides, and anti-hypertensive therapy.

Abbreviations: N (number of fractures), Interquartile range (IQR), person-years (PYs), subhazard ratio (SHR), adjusted (adj).