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. 2017 Jun 13;12:4433–4442. doi: 10.2147/IJN.S134897

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© 2017 Yan et al. This work is published and licensed by Dove Medical Press Limited

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Effects of CB on ZnO-NP-induced HO-1 and PECAM-1 expression of HCAEC in coculture.

Notes: (A) HCAECs in monoculture and A549 cells in coculture were incubated with ZnO-NPs for 24 h. Levels of intracellular zinc contents in HEAEC were measured using flame atomic absorption spectrometry (*compared to control group, P<0.05). A549 cells in coculture were preincubated with CB or vehicle control, prior to ZnO-NP (40 μg/mL) treatment for 24 h. HO-1 (B) and PECAM-1 (C) expression of the supernatant in basolateral chamber were measured using ELISA (*compared to the vehicle control group, P<0.05; ^▲compared to ZnO-NP-treated cells without CB treatment, P<0.05).

Abbreviations: CB, cytochalasin B; ZnO-NPs, zinc oxide nanoparticles; HO-1, heme oxygenase-1; PECAM-1, platelet endothelial cell adhesion molecules-1; HCAEC, human coronary artery endothelial cells; A549, human alveolar type II epithelial cells; ELISA, enzyme-linked immunosorbent assay.