Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jun 19;7:3793. doi: 10.1038/s41598-017-04006-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

RNA-Seq analysis of GFP⁺ LRCs and GFP⁻ corneal epithelial cells from K5tTA × TRE-H2BGFP highlights the up-regulated and down-regulated genes in GFP⁺ LRCs over time. (A) Heatmap of 651 up regulated genes in GFP⁺ LRCs showing differences in gene expression between GFP⁻ and GFP⁺ cells represented in a single column at each chase period. The colors of the heat map representing single genes changing from blue to red across the chase periods indicate enrichment of gene expression in GFP⁺ LRCs. The table enlists pathways and genes involved in stem cell activation, maintenance and proliferation in GFP⁺ LRCs. (B) Heatmap of 135 down regulated genes in GFP⁺ LRCs. Blue represents low expression in GFP⁺, and red high expression in GFP⁺. The table indicates key genes involved in cell division and differentiation. Highlighted green boxes in the table represent significant high expression in GFP⁺ LRCs; Grey boxes represent significant high expression in GFP⁻ cells; No color indicates no significant difference between GFP⁺ and GFP⁻ cornea cells.