Table 5.

Sequence conservation of residues around new binding site evaluated by sequence alignment for different H1N1 influenza virus strains in recent 30-year period of time.

Residue	Entropy data*	Residue	Entropy data
Lys278(HA1)	0.42889	Pro304(HA1)	0.06495
Ser289(HA1)	0.04048	Ile55(HA2)	0.05048
Leu290(HA1)	0.03910	Glu56(HA2)	0.05353
Pro291(HA1)	0.03809	Thr60(HA2)	0.05977

*low entropy data means high conservation.