Skip to main content
. 2017 Jun 20;4:42. doi: 10.3389/fmolb.2017.00042

Figure 5.

Figure 5

The AAA-ATPase ring of the human proteasome. (A) The AAA-ATPase is located on the alpha ring of the CP. The catalytic beta-subunits are colored in red, the alpha-subunits in blue. A magnified view of the AAA-ATPase ring is shown on the right. Coiled-coils of N-terminal regions reach out to other RP subunits. (B) The AAA-ATPase subunit colored in cyan is bound to ADP (red ellipse), while the other five AAA-ATPase subunits are bound to ATP (red box). (C) Rpn3 acts as sensor to induce conformational changes in the RP upon substrate docking into the ATPase ring (shown as a surface diagram). The C-terminus of Rpn3 colored in red is close to the pore of the N-ring (white line) and the O-ring (yellow line). This figure was prepared using the PDB ID: 5L4G through PyMOL (Ver. 1.8.0.2) molecular graphics software (Schrodinger, LLC, New York).