Table 1.

Combined use of GABA and sitagliptin elevates plasma insulin and GLP-1 levels, while decreases plasma glucagon levels.

	Baseline	Water	GABA	Sita	GABA+Sita	F-values	P-values
Insulin (ng/ml)	0.67 ± 0.08	0.30 ± 0.02	0.52 ± 0.14ˆ*	0.44 ± 0.10ˆ*#	0.77 ± 0.22ˆ**	8.43	<0.001
Glucagon (pg/ml)	175.0 ± 21.9	383.8 ± 37.5	212.7 ± 14.5ˆ**	227.8 ± 14.8ˆ**#	199.9 ± 17.1ˆ**	54.89	<0.0001
GLP-1 (pmol/L)	5.26 ± 1.31	2.13 ± 0.43	2.94 ± 0.76	5.10 ± 0.45ˆ**##	6.93 ± 0.29ˆ***	19.28	<0.001

Data are Mean ± SD. ^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001 vs. diabetic control group (Water group); ^#P < 0.05, ^##P < 0.01 vs. GABA+sitagliptin treated group.